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Moreover, recruitment of this triple combination therapy regimen can reduce the incidence of inflammation and skin irritation induced by hydroquinone or retinoids (Gupta et al., 2006)

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This includes D-penicillamine (distributed under the brand named including Cuprimine, a capsule, and Depen, a tablet), which was the first oral therapy developed for Wilson disease

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J Appl Toxicol JAT 32:505520 Laaksonen R, Katajamaa M, Piv H, Sysi-Aho M, Saarinen L, Junni P, Ltjohann D, Smet J, Van Coster R, Seppnen-Laakso T, Lehtimki T, Soini J, Orei M (2006) A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle