doi: 10.1073/pnas.0500735102
In diabetes, reduced GPx in kidneys exacerbates nephropathy, with oxidative damage fueling complications
Rodent studies have shown BPC-157 increases expression of EGF (epidermal growth factor) receptor signaling in intestinal tissue
However, several studies have shown that GLS2 is highly expressed in triple-negative basal-like breast cancer (TNBC) and metastatic lung cancer and that it confers radioresistance in advanced human cervical cancer cells, suggesting that GLS2 may reduce reactive oxygen species (ROS) levels by increasing the level of cellular reduced glutathione (GSH), NADH, or NADPH 14,15,16
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