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Under normal conditions, Nrf2 is anchored in the cytosol through its interaction with Kelch-like ECH-associated protein 1 (Keap1), which serves as a substrate adapter protein for an E3 ubiquitin ligase complex (Zhang et al

Vitamin D & Glutathione A recent study published in Antioxidants & Redox Signaling found a strong correlation between low glutathione levels and Vitamin D absorption from supplements

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And I don't know, it's a possibility, it hasn't been proven, but I think that it's certainly an interesting hypothesis that should be looked at