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The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

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Interestingly, L-NAME appears to be more sensitive to BPC 157 application providing that BPC 157 more than nullifies the effect of L-NAME (i.e., L-NAME + BPC 157