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Targeting cell death: pyroptosis, ferroptosis, apoptosis and necroptosis in osteoarthritis

169172, 2004 [54] E

It is present in every cell and plays a critical role in: Neutralising free radicals Supporting liver detoxification Protecting skin cells from oxidative stress Helping maintain even skin tone Lifestyle factors such as pollution, stress, aging, poor sleep, and UV exposure can reduce glutathione levels, which is why many people use a glutathione supplement to support their antioxidant defense

GGCT, a key enzyme in tumor metabolism, has been reported to be upregulated in several cancers, and its depletion can exert anticancer effects

The scratch assay showed that ferroptosis inhibition reversed the IL-1-induced decrease in cell migration (Fig