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The apoptosis assay using flow cytometry was performed according to the vendor's protocol (BD Pharmingen, BD Biosciences, San Jose, USA)

Epidermal growth factor (EGF) and EGF receptor (EGFR) EGF is a mediator with crucial roles in the proliferation, survival, differentiation, and migration of vascular endothelial cells, through EGFR binding

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the following properties are derived from preclinical data