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Unpublished studies have also demonstrated that the IGF-1Rs of PPP treated cells are undergoing rapid downregulation

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The low IGF-I levels is caused by nutritionally acquired hepatic GH resistance from intra-portal hypoinsulinemia ( Table 1

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Track metabolic markers: fasting glucose, HbA1c, fasting insulin, lipid panel, body composition by DXA or bioimpedance, and waist circumference to measure meaningful change