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After the study, all models were histologically examined

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Enterohepatic circulation further influences LT4 metabolism, with conjugation via glucuronidation and sulfation in the liver, secretion into bile, and partial reabsorption by the intestinal flora (Eghtedari And Correa 2023)

This fundamental limitation is why traditional treatments are often about managing symptoms or removing the damaged tissue (a meniscectomy), not true regeneration

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