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Crystallisation and structure determination of TRF1 TRFH TRF1 TRFH crystals in the P3 1 21 space group were grown by sitting drop vapour diffusion in SWISSCI 3-drop plates using similar crystallisation conditions to those described previously 31

Particularly evident in the case of anti-p-Tyr immunostaining, there was an outwardly increasing gradient of IHC staining intensity along the axis from the core towards the peripheral invasive front (Figure 5A)

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