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Out of 20 studies that it looked at, however, 12 were funded by manufacturing companies so there is a lack of independent research. The level of skepticism around any goodwill or scientific efforts by tobacco companies remains high, not least, as Britains Royal College of Physicians puts it, because there is no firewall between a good tobacco industry that is marketing harm-reduction products in the U.K

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However, these studies are primarily in cell culture and animal models or in human studies with small number of subjects

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