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The M1 phenotype of microglia is responsible for synthesizing and releasing various cytokines, including prostaglandin E2 (PGE2), CRP, and TNF-alpha, into the bloodstream (Attwells et al., 2020)

Acknowledgments We would like to thank the Director General of Health Malaysia for his permission to publish this article

As compounded semaglutide is manufactured in compounding pharmacies, its quality varies among pharmacies, depending on the standard of the compounding pharmacy

The SURMOUNT-1 data shows that weight loss continues in a roughly linear fashion through week 40, with the rate slowing gradually after that