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156 It has been proposed that oxidative stress can inactivate HDAC2 by means of nitration or carboxylation and that HDAC2 is phosphorylated, ubiquitinated, and degraded as a consequence of cigarette smoke exposure

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This amounts to 8 million people a year, including 1.2 million people who are exposed to second-hand smoke

It would also cause a 25 percent reduction in the number of new high school age smokers, and a 15 percent decline in the number of new smokers under the age of 21

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