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The second order rate constant k ox for the nonenzymatic reaction between GSSG and roGFP2 WT (SH) 2 was 0.7 M 1 s 1 (Fig

However, regardless of their definite positive effects, therapeutic applications of natural neurotrophins like NGF and BDNF, for treatment of neurodegenerative diseases, are limited due to their inability to cross blood brain barrier and also susceptibility to degradation by peripheral peptidases (Tomioka et al., 2014)

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Xia H, Green DR, Zou W