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Patients with Fitzpatrick IV-VI skin should be monitored for potential irritation during initial use, particularly in combination with other actives, and formulations should be pH-controlled (pH 3.5 or lower for efficacy without excessive irritation)

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For example, using the chronic unpredictable mild stress (CUMS) model, studies have demonstrated that specific Chinese medicines significantly improve depressive-like behaviors in animals

Factors such as stress, poor diet, illness, and sun exposure accelerate this depletion leaving skin looking dull, uneven, or prematurely aged