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The guidance does not expressly define any new mandates or prohibitions, but in an accompanying statement, CMS Administrator Dr

doi: 10.1007/s00018-022-04353-8 462 YamakiH.YamaguchiM.TsuruoT.YamaguchiH

Trseid, M., Andersen, G

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79 , 80 Additionally, CAFs contribute to immunosuppression by secreting immunomodulatory factors, which warrants further research to determine if targeting immune checkpoints within the TME could reverse this resistance