Sermorelin enhances the bodys natural production of growth hormone by stimulating the pituitary gland, promoting cellular growth, and aiding in tissue repair Tesamorelin is primarily prescribed for HIV patients to reduce abdominal fat accumulation, enhancing their overall well-being
Neuropsychopharmacology 2014;39:310011
Ipamorelin : 2nd-generation GHRP, highly selective for GHS-R1a, no significant impact on cortisol or prolactin the current darling of modern protocols GHRP-6 : first generation, potent but triggers marked hunger (ghrelin-like action on the arcuate nucleus) and slight prolactin/cortisol elevation Hexarelin : most potent on acute GH release, but rapid GHS-R1a desensitization after prolonged use and more pronounced cortisol elevation Key point: GHRPs add an amplifying signal that potentiates GHRH, but chronic monotherapy triggers receptor down-regulation
Nevertheless, metformin remains the typical first-line choice because of its well-established safety profile, efficacy, low cost, and wide accessibility (Wexler 2021b)
These include: Known liver disease (e.g., NAFLD, hepatitis) Chronic exposure to environmental toxins Chronic fatigue or immune dysfunction Metabolic conditions with elevated oxidative stress In these cases, a patient might benefit from targeted testing, such as liver function panels, oxidative stress markers, and nutrient levels
