Users should weigh whether the enhanced results justify the additional expense based on their injury severity and recovery goals
Expanded options for pathway profiling are in the graphic below: Functionality biomarkers Cytochrome P450 enzyme activity Albumin production Urea production Clinical liver health biomarkers Lactose dehydrogenase (LDH) release Adenosine Triphosphate (ATP) Aspartate Transferase (AST)/Alanine amino transferase (ALT) Optional profiling analysis Quantitative PCR Transcriptomics Oxidative stress Mitochondrial dysfunction Steatosis Bile acid synthesis/ transport dysregulation Inflammatory response (Human DILI assay only) Proven predictability, reliability and robustness Using a panel of IQ MPS Consortium-recommended reference compounds, the PhysioMimix DILI assay delivered 100% sensitivity, 85% accuracy and 100% precision, outperforming other in vitro approaches
Srivatsan R, Das S, Gadde R, Manoj-Kumar K, Taduri S, Rao N, et al
Research demonstrates that along with oxidative stress, intense activity decreases levels of glutathione, our bodys homemade antioxidant
Sulforaphane as a potential therapeutic agent: a comprehensive analysis of clinical trials and mechanistic insights