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These variations help explain why two pouches with the same labelled nicotine content may deliver nicotine differently

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Each of the 18 healthy, adult nonsmokers who volunteered for the study started off by getting two identical pills a day, labeled "A" and "B." They were told the nonplacebo might contain any number of substances, including caffeine, ginseng, or nicotine

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A smoking machine uses an air pump to smoke a cigarette, and the content of the smoke is analysed by the machine