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Additionally, while peptides show promising benefits in areas like muscle recovery, inflammation reduction, and gut healing, the researchparticularly in human trialsis still emerging, making expert guidance essential to avoid unwanted side effects or ineffective use

Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency

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Ethics declarations Ethics approval and consent to participate All animal procedures were approved by the ethical committee of the West China Hospital of Sichuan University (No

DOI: 10.1016/j.cgh.2017.06.037 Caio, G., Volta, U., Sapone, A., Leffler, D