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Their use constitutes off-label administration, and the current clinical evidence for their efficacy in this context is limited

However, as will be elaborated upon in the subsequent sections, the majority of patients with MDD do not exhibit a classical IRS profile, as evidenced by elevated scores in M1, Th1, and Th17 or IRS profiles, although most MDD patients present with immune-linked neurotoxicity profiles

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The sheared XBP1 mRNA then translocates to the nucleus, translating into the active transcription factor XBP1s