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Notably, breast cancer cells exhibit elevated aerobic respiration due to their highly active mitochondrial metabolism, which may potentiate tumour angiogenesis via the cuproptosis pathway, thereby fostering a tumour-promoting microenvironment [95]

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This overabundance of lactate is associated with a worsened disease state, potentially by creating a pro-inflammatory microenvironment, disrupting the balance of short-chain fatty acid production, and directly impairing epithelial barrier function [130]

The Iranian version of 12-item short form health survey (SF-12): factor structure, internal consistency and construct validity

Wake R, Miyaoka T, Inagaki T, Furuya M, Ieda M, Liaury K, Kishi K, Horiguchi J (2013) Yokukansan (TJ-54) for irritability associated with pervasive developmental disorder in children and adolescents: A 12-week prospective, open-label study