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In part because of Italy's relative economic backwardness, but also I argue because of a particular Italian attitude relative to risk, Italians responded slowly to the body of evidence that accumulated from the early 1950s linking cigarette smoking to lung cancer and other deadly diseases

"We observed a smoke-related defect in the enzymes that produce hydrogen sulfide, a vital signal transmitter [messenger] that helps regulate organ development," Chand said

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Smokeless tobacco use has been increasing gradually for the past few years