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In non-responders at weeks 9-12, median salivary cotinine concentrations at week 12 were lower in the varenicline group (114 ng/ml) than in the placebo group (307 ng/ml), suggesting less nicotine use in the varenicline group, though these differences were not significant (P=0.193) because of large variability in cotinine concentrations

Nicotine alters male reproductive hormones in male albino rats: The role of cessation National Heart, Lung, and Blood Institute (2022)

GBD data also show that asthma is the most prevalent chronic airway disease, affecting over 260 million people worldwide [3]

I didnt get incredibly anxious or run to the gas station to eat a whole pack

While the authors argue that these estimates likely remain current, more recent data could potentially yield slightly different results