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doi: 10.3390/pharmaceutics11120681 166 XuHYuWBGaoYZhangMJMalhotraAYuWH

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Acute emergencies from local anesthetics are generally related to high plasma levels encountered during therapeutic use of local anesthetics or to unintended subarachnoid injection of local anesthetic solution (see ADVERSE REACTIONS, WARNINGS, and PRECAUTIONS)