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The peptide stimulates expression of early growth response 1 (EGR-1) gene, which regulates cytokine and growth factor generation along with early extracellular matrix formation, while simultaneously inducing its repressor NAB2 to prevent excessive angiogenic signaling

Robertson, R., Zhou, H., Zhang, T

2a, e): social motivation test (phase 1) and the social recognition test (phase2)

We think that peptide therapy works best when it is part of a whole approach

In wild-type mice, Cx32 abundance in hepatocytes decreased substantially as early as 1-h post-APAP treatment, reaching a 20% reduction compared to the steady-state or control group