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Diseases like HIV/AIDS, chronic hepatitis, and certain autoimmune disorders contribute to increased oxidative burden, depleting the body's antioxidant reserves

Other attempts at directly or indirectly targeting MYC have included knockdown, protein/protein and DNA interaction inhibitors, and translation and expression regulation [74]

Therefore, developing anti-AGE molecules, adopting AGE-restricted diets, and incorporating exercise regimens may offer innovative approaches to mitigate AGEs-induced fertility impairments in PCOS patients

10.1038/nrm.2017.129 Nat

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