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The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Year trends in the use of DHTs The use of DHTs in interventional trials for the selected rare diseases first appeared in 2009 and showed a gradual but consistent increase through 2019 (Fig

Current focus areas include: Genetic risk stratification in Type 2 diabetes Pharmacogenomics influencing drug response Biomarker-guided treatment intensification Continuous metabolic phenotyping However, real-world challenges persist: Cost-effectiveness Accessibility across regions Standardization of predictive models Translational gaps between research and practice The science is accelerating