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Perkins GD et al (2018): A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest

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In that trial, 74% of participants in the control group who received CRS with varenicline achieved continuous abstinence from weeks 8 to 12, mirroring outcomes from the earlier observational study 5

As for e-cigs, although there is no smoke produced, the aerosol spray contents are spread to the bystanders in the nearby capacity of people using e-cigs, suggesting that some second hand exposure does exist