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2, MTHFR catalyzes the physiologically irreversible reduction of 5,10-methylene THF to 5-methyltetrahydrofolate (5-methyl THF), and plays a critical role in one-carbon metabolism for the reaction of producing methyl groups to participate in epigenetic regulation 18

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Ice after injection for 5 minutes

Signal transduction and targeted therapy, 2017, 2(1): 19

TLR2 and TLR3 activation also causes inhibition and decreased expression of intestinal 5-HT transporters (SERTs), resulting in extracellular accumulation of 5-HT and activation of 5-HT receptors, generating increased motility, nausea and intestinal secretions (181184)