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An in vivo experiment based on the acute HH mouse model has confirmed that prophylactic administration of tetrahydrocurcumin can alleviate acute HH-induced brain edema, reduce the levels of inflammatory factors IL-1 and TNF-, increase SOD activity to enhance hypoxia resistance, and inhibit the NF-B/VEGF/MMP-9 pathway to reduce HH-induced brain edema and inflammation, thereby exerting neuroprotective effects ( Curcuma longa and its active metabolites, through multi-target regulation of inflammatory responses and BBB protection, may provide a novel strategy for the pathological intervention of brain edema in hypoxic environments at high altitudes
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The rostral two burr holes were placed just basal from the posterior interocular line, the basal two burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the middle two burr holes were placed in the line between the basal and rostral burr holes
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