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Further research is needed to fully understand its mechanisms of action, including its ability to improve mental stamina, and determine its potential therapeutic applications, particularly related to its ability to cross the blood-brain barrier and exert neurotrophic activity

These are mechanistic findings from peer-reviewed literature

FDA Guidance Document

Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)

When enough excitatory input accumulates, the neuron sends its own electrical signal down the axon