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doi: 10.2337/db23-0926

Watts, A

Concurrently, SUA-induced oxidative stress may impair full AMPK activation via post-translational modifications, leading to a condition in which activation cues persist but functional AMPK activity remains insufficient

This insulin resistance further promotes lipolysis in adipose tissue, releasing excessive FFAs that subsequently induce OS ( In contrast to LEP, the expression of APN is inversely related to the degree of obesity, and usually there is a decreased expression of APN in obese patients ( Figure 2b

Triglycerides, a blood fat marker linked to cardiovascular disease, dropped by over 40% in retatrutide participants at the higher doses