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As a C-terminal tripeptide of alpha-MSH, KPV engages the melanocortin systemspecifically MC1R and potentially MC3Rproducing downstream suppression of pro-inflammatory cytokines including IL-1, IL-6, and TNF-

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Statistical analysis Data were preliminarily tested for normality with KSmirnov test, and descriptive data were accordingly expressed as means.d., or median with interquartile range