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The authors concluded that the senescent microenvironment maintained by SASP and p53-pS15 signalling promotes keloid aggressiveness and relapse, and that FOXO4-DRI targets this mechanism selectively

Acknowledgements We sincerely thank Ya-Hui Tsai, PhD, research specialist in the Division of Pediatric Surgery, Department of Surgery, Far-Eastern Memorial Hospital for editing the figures in the manuscript

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