Moreover, iron overload could be alleviated by the only known iron exporter, ferroportin (FPN) that promotes iron transport out of cells and inhibits the production of ROS (Geng et al., 2018)
Timing and specific drugs matter
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Evidence suggests multiple interrelated pathways of liver injury: Nicotine-induced injury : Nicotine is metabolized in the liver via CYP2A6, where it activates 7-nicotinic acetylcholine receptors (7-nAChR), leading to oxidative stress, mitochondrial dysfunction, and pro-fibrotic signaling [36, 125, 126]