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Beyond bioactive constituents and overall dietary patterns, certain dietary strategies, such as the ketogenic diet, may influence neurocognitive outcomes by deliberately shifting systemic metabolism towards physiological ketosis, thereby increasing circulating ketone bodies and providing a distinct mechanistic framework [67, 68]

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A subsequent meta-analysis of TSPO PET studies confirmed increased microglial activation, particularly in the anterior cingulate, prefrontal and temporal cortices, insula and hippocampus [280]

Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase

The Wolverine Blend's multi-pathway approach can address several of these simultaneously