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Week 24 Primary effects begin to manifest

Some people notice improved energy or less tingling within days, but meaningful relief of numbness or burning from neuropathy can take several weeks to months

It was effectively applied either immediately (prophylactically) after paracetamol challenge or (therapeutically) administered after a 3 h period had elapsed (note, the maximum depletion of hepatic glutathione occurred 3 h after acute paracetamol dosing (37))