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FIGURE 7 8.1 Hesperidin Hesperidin (4-methoxy-7-O-rutinosyl-3,5-dihydroxyflavanone) is a natural bioflavonoid primarily found in citrus fruits such as fingered citron ( Multiple studies have shed light on the diverse mechanisms underlying hesperidins antidepressant potential

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GPX4, a downstream target of GSH action, functions as a unique intracellular antioxidant enzyme acting on membrane lipid repair, which is able to directly reduce peroxidized phospholipids produced in cell membranes (88,89), and it converts toxic lipid ROS into non-toxic lipid alcohols with the aid of GSH, which thereby reduces the level of oxidative damage to cells (90)

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