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a-c , Autochthonous tumors from MMTV-PyMT Gclc f/f Rosa26-CreERT2 mice were excised and subcutaneously transplanted into flanks of wild-type C57BL/6 mice, which were treated with vehicle (corn oil

Likewise, during liver fibrosis, hepatic stellate cells (HSC) stimulated by TGF- induced palmitoylation of hexokinase 1 (HK1) and secretion through large EVs in a TSG101-dependent manner

Past studies have shown that various pathways associated with the initiation of ferroptosis ultimately converge to suppress cystine import through the inhibition of cystine-glutamate antiporter (system Xc ), which is reportedly necessary for glutathione biosynthesis (Dixon et al

Their antioxidative properties stem from neutralizing ROS via direct radical scavenging or by enhancing endogenous antioxidant defense mechanisms, such as the Nrf2 pathway, reducing oxidative cellular damage 189

Metabolomics: the apogee of the omics trilogy