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17 A key characteristics of pain related to IC/BPS is that the pain is worsened with bladder filling (painful bladder filling) and/or their strong urge to urinate was due to pain, pressure, or discomfort (painful urgency)

We were interested in examining whether the administration of TAT-DAT NT can improve such behavior deficits in SHR rats using the same Y-maze test

the effect was abolished by an HGF antagonist and by Akt, TOR and MEK inhibitors, again pointing to the same axis

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generally, if its close to the next dose, skip the missed dose (do not double up doses)