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Due to its ability to prevent oxidative stress caused by free radicals, alpha-lipoic acid plays a key role in maintaining skin health and preventing the signs of aging

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Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression

To obtain crystals of the AsA-bound protein, Cys20-mutated OsDHAR (C20S) was used, which lacks reductase activity but exhibits AsA binding activity