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This disorder is associated with mitochondrial abnormalities of respiratory function, Ca 2+ cycling, ROS/RNS production, mPTP opening, activation of different mechanisms of programmed cell death, disbalance of the processes of mitochondrial fusion, fission, and autophagy, and disturbances in synaptogenesis and synaptic transmission which affect the brain development and cause behavioral deficits

Tran (Cham, Switcherland: Springer International Publishing), 309329

Age related changes in weight and the concentrations of zinc and copper in the brain of the adult rat

Aplin JD, Stevens A

Its potent properties also help combat oxidative st