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These guidelines, while a starting point, are often based on a one-size-fits-all model (e.g., 8 or 12-weekly injections) that does not work for all patients

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[DOI] [PMC free article] [PubMed] [Google Scholar] Summey BT, Graff RD, Lai T-S, Greenberg CS, Lee GM (2002) Tissue transglutaminase localization and activity regulation in the extracellular matrix of articular cartilage