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Emerging roles of astrocytes in neural circuit development
Unlike synthetic drugs that force a specific response, peptides simply enhance the signaling pathways your cells already use
Our findings indicate that FOXO4-DRI promotes apoptosis in senescent cells by disrupting the FOXO4-P53 interaction, thereby releasing and phosphorylating P53, which then translocates to the cytoplasm
Funding This project was financially supported by Fujian Province Natural Science Foundation (Grant number: 2020J01128), Special Health Subsidy of Fujian Provincial Finance Department (Grant number: 2100206 50502 302), HealthCare Youth and Middle-aged Leading Talent Project of Fujian Province Healthcare Youth and Middle-aged Training Project of Fujian Province (Grant number: 2021GGB014), Joint Funds for the Innovation of Science and Technology, Fujian Province (Grant number: 2021Y9180, 2021Y9169) and Science and Technology Project of Fuzhou city (Grant number: 2022-S-079)
The degradation rate and half-life (t1/2) of the drugs were determined by measuring the decrease in area under the curve (AUC) at their retention times [2]
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