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HO-1 attenuates the generation of oxidants by diabetes and uncouples nitric oxide synthase (NOS) to mediate the inhibition of PKC and NADPH oxidase in the endothelial cell (43, 46)

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity

These findings were challenged by a more recent in vitro study, using fecal microbiota from healthy donors (Peng et al., 2024)

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The treatment protocol involved weekly injections for 4-7 weeks, suggesting that tissue regeneration effects require sustained exposure over multiple weeks