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Muscle tissue contains more nerve endings than subcutaneous fat, which may contribute to greater injection-related discomfort

DSIP is a naturally occurring neuropeptide commonly discussed in research contexts around sleep regulation, stress response, and restorative routines

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Therefore, unlike the adenovirus, lentivirus, and other AAV serotypes, the AAV9 vector is able to effectively avoid two main issues: the need for invasive injection, and compromising the integrity of the BBB, although its transduction efficiency diminishes with increasing age [156]