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A controlled study (PMID: 7777652) found that DSIP did not significantly affect CRH- or meal-induced ACTH and cortisol secretionindicating DSIP does not measurably blunt the human cortisol response, contrary to stress-protective effects suggested by some animal studies

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In another study, compared to the control group, GHK treatment groups (1 or 10 mg/kg) demonstrated decreased neuronal apoptosis and neurological deficits in rat brains induced by intracerebral hemorrhage (ICH) injury