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Albumin increased fungal cytotoxicity, particularly of otherwise low damaging clinical isolates, whereas results were less consistent with SC5314, likely due to albumin neutralizing candidalysin 19 of this highly efficient toxin producing strain 3

The carboxyl group of the cysteine residue is attached to glycine via a normal peptide bond

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Phase 3 monotherapy available Feature Expected GI burden Cagrilintide + Retatrutide Very high CagriSema (Cag + Sema) High Retatrutide Alone High Feature Dysesthesia risk Cagrilintide + Retatrutide Yes (retatrutide component) CagriSema (Cag + Sema) No Retatrutide Alone Yes Feature Injections per week Cagrilintide + Retatrutide 2 (separate) or 1 (pre-blend) CagriSema (Cag + Sema) 1 or 2 Retatrutide Alone 1 Feature Regulatory status Cagrilintide + Retatrutide Neither approved