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It arises from a combination of endocrine, inflammatory, neural, and intracellular mechanisms (Tong et al., 2022) and is linked to lifestyle factors, including diet (Bruckner et al., 2024)

TB-500 supports: cell migration to injury sites functional tissue remodeling reduced fibrosis improved tissue glide and flexibility This makes TB-500 particularly valuable after prolotherapy or PRP, when remodeling quality determines long-term success

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[DOI] [PubMed] [Google Scholar] 156.Elmengaard B, Bechtold JE, Soballe K