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Alpha-MSH interacts with various melanocortin receptors (MCRs) in the body, affecting multiple physiological processes

Do not use any other diluent unless instructed by your prescribing physician

Retrieved from Foundation for Peripheral Neuropathy website

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FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis